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Analysis of a Gene Regulatory Network Model With Time Delay Using the Secant Condition

By Mehmet Eren Ahsen, Hitay Özbay, and Silviu-Iulian Niculescu
Published October 4, 2016.

Gene Regulatory Network Model

A cyclic model for gene regulatory networks with time delayed negative feedback is analyzed using an extension of the so-called secant condition, which is originally developed for systems without time delays. It is shown that sufficient conditions obtained earlier for delay-independent local stability can be further improved for homogenous networks to obtain delay-dependent necessary and sufficient conditions, which are expressed in terms of the parameters of the Hill-type nonlinearity.

View the full article at IEEE Xplore.

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