Issue 3

SCT Promoter Methylation Is a Highly Discriminative Biomarker for Lung and Many Other Cancers

By Adwait Sathe, Yu-an Zhang, Xiaotu Ma, Pradipta Ray, Daniela Cadinu, Yi-wei Wang, Xiao Yao, Xiaoyun Liu, Hao Tang, Yunfei Wang, Ying Huang, Changning Liu, Jin Gu, Martin Akerman, Yifan Mo, Chao Cheng, Zhenyu Xuan, Lei Chen, Guanghua Xiao, Yang Xie, Luc Girard, Hongyang Wang, Stephen Lam, Ignacio I. Wistuba, Li Zhang, Adi F. Gazdar, and Michael Q. Zhang
Published October 7, 2015.

Aberrant DNA methylation has long been implicated in cancers. In this letter, we present a highly discriminative DNA methylation biomarker for non-small cell lung cancers (NSCLCs) and 14 other cancers. Based on 69 NSCLC cell lines and 257 cancer-free lung tissues, we identified a CpG island in SCT gene promoter, which was verified by qMSP experiment in 15 NSCLC cell lines and three immortalized human respiratory epithelium cells. In addition, we found that the SCT promoter was methylated in 23 cancer cell lines involving >10 cancer types profiled by ENCODE. We found that the SCT promoter is hypermethylated in primary tumors from TCGA lung cancer cohort. In addition, we found that SCT promoter is methylated at high frequencies in 15 malignancies and is not methylated in ~1000 non-cancerous tissues across >30 organ types. This letter indicates that SCT promoter methylation is a highly discriminative biomarker for lung and many other cancers.

View the full article at IEEE Xplore

University of Minnesota - Neuromodulation Faculty Scholars - Learn More
Life Sciences Letters

About the
Life Sciences Letters

IEEE Life Sciences Letters (LSL) is a new digital, peer reviewed open access journal. The LSL publication will focus on shorter papers with a quick turnaround, in the area of personalized medicine, pharmaceutical engineering, synthetic biology, and systems biology. Learn more about the scope here. Information for authors can be found here.

Editor-in-Chief

Frank DoyleEditor-in-Chief
Frank Doyle

Deputy Editor

Mathukumalli VidyasagarDeputy Editor
Mathukumalli Vidyasagar

Senior Editors

Leroy HoodSenior Editor for Personalized Medicine
Leroy Hood

Richard D. BraatzSenior Editor for Pharmaceutical Engineering
Richard D. Braatz

Ron WeissSenior Editor for Synthetic Biology
Ron Weiss

Hiroaki KitanoSenior Editor for Systems Biology
Hiroaki Kitano

For biographies and the list of all of the editors, click here.